
WHAT IS ADHERENCE?
Adherence to medical plans for older people
A European Innovation Partnership on Active and Healthy Ageing priority
The overall adherence process consists of:*
Adherence is the extent to which a person's behaviour corresponds with agreed recommendations 
from a healthcare professional. It encompasses:
APPROPRIATENESS  INITIATION IMPLEMENTATION PERSISTENCE
prescribing the right
treatment to the patient
filling the prescription
in the hospital or pharmacy
taking the medicines
following the prescription
continuing the treatment
for its whole duration
medication physical activity diet visits to health professionals
*e.g. when taking medicines
WHY ARE WE WORKING ON ADHERENCE…
… IN AN AGEING POPULATION?
of patients typically 
take their medications 
as prescribed 
premature deaths per 
year among Europeans are 
related to non-adherence
"Increasing the effectiveness of adherence interventions may have a far greater impact 
on the health of the population than any improvement in specific medical treatments"
Multimorbidity, the co-occurrence of multiple diseases, affects more than half 
of the elderly population
Polypharmacy, the simultaneous use of multiple medicines by a single patient, 
for one or more conditions, is common in older people: 40% of people aged 65
and over consume between five and nine medicines per week
Share of population
over 65 is increasing
in OECD countries:
28,4%
18,2%
28.4%
18.2%
2013 2060
Eurostat
50% 200,000
WHO report on adherence to long-term therapies
Costing statement: Medicines adherence, NICE
ONLY NEARLY
Health illiteracy (lack of understanding of one’s 
condition and significance) and health beliefs
Non-adherence can be motivated 
by several factors:
WHY DO PATIENTS NOT ADHERE TO THEIR MEDICAL PLANS?
Access to healthcare (e.g. cost of medication, 
geographical availability)
Misunderstanding of prescription instructions
Forgetfulness
Complex regime (high number of medicines
taken at different times) or restrictive 
precautions (e.g. no alcohol or cheese)
Reduction, fluctuation or disappearance 
of symptoms
Adverse effects (real or imagined)
?
!
?
WHAT HAPPENS IF PATIENTS DO NOT ADHERE TO THEIR MEDICAL PLANS?
Consequences 
for patients
potential harm or little clinical benefit
risks due to additional prescribing
development of resistance 
to therapy (e.g. antibiotics)
!
Consequences for  
the healthcare system
the cost of initial care service
 medicines dispensed but not used
increased use of health services
in cases of worsening of symptoms
!
Increased health costs due to:
The European Innovation Partnership on Active and Healthy Ageing (EIP on AHA)
The European Innovation Partnership on Active and Healthy Ageing (EIP on AHA), set up in 2012, gathers stakeholders at EU, national and regional level from the public and 
private sector across different policy areas. Together they share knowledge and expertise on common interests and engage in activities and projects to find innovative solutions 
that meet the needs of the ageing population.
Under the framework of the EIP on AHA, the Action Group on adherence to medical plans works to improve the quality of life and health outcomes of older people by supporting 
patient adherence to care plans while empowering them and delivering improvements in the healthcare system.
https://webgate.ec.europa.eu/eipaha/
• Health literacy and lifestyle 
interventions (including ICT tools) 
around medicines, physical activity 
& nutrition 
• Medication review for 
appropriateness of prescription
• Web-based social platforms
• Information and counselling 
campaigns
HOW ARE WE IMPROVING ADHERENCE TO MEDICAL PLANS IN OLDER PEOPLE?
hospital pharmacy
CardiologistGP Orthopaedist
Prescription of several drugs, 
physical activity & nutrition advice
PROBLEMS
ENCOUNTERED
WORK UNDERTAKEN 
BY THE EIP ON AHA
The European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) supports public 
and private actors across the EU to improve adherence to medical plans through a multidisciplinary 
approach that impacts upon each step of the patient’s journey through the healthcare system.
• System works in silos
• Prescriptions not cross-checked
• Electronic prescription
• Collaborative digital platforms 
between HCP
• Integrated care approaches
• Decision-support tools for
appropriateness of prescription 
(e.g. guidelines, dispensing 
protocols, risk stratification)
• Patient electronic health records
• Training programmes for HCP
• Patient misunderstands  
the health problem or 
prescription instructions
• Patient forgets to take 
medication
• Patient has a complex 
medication regime
• Patient misunderstands 
prescription instructions
• Patient has an adverse 
drug reaction 
• More knowledge and evidence 
needed on adherence related 
issues, especially in 
polymedicated patients
• Need to identify most effective 
interventions
•
 Electronic 
devices
 and alert 
systems
•
 Age-friendly medicines 
and packaging 
(e.g. Personalised 
Dosage Sytems)
•
 Adherence 
monitoring
 
platforms for HCP
•
 Medication review and 
reconciliation protocols
•
 Pharmacovigilance
 tools
•
 
Indicators/algorithms
 on 
appropriate prescription, adherence 
measurement, polypharmacy
•
 Scientific 
studies
 on adherence 
related issues
•
 
Data repositories
•
 
Cost-effectiveness 
and 
intervention analyses
Old person
with several
conditions
Focus on prescription of drugs
Patient fills in prescription of drugs
at hospital or community pharmacy
Patient seeks assistance
in case of problems with medication
Visits to different healthcare professionals (HCP)
?
!
H